Titlebook: Non-Biological Complex Drugs; The Science and the Daan J.A. Crommelin,Jon S. B. de Vlieger Book 2015 Springer International Publishing Swi

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Gerrit Borchardelling of some major non-idealities that limit thephysical realisation of pipelined ADCs and the proposal, developmentand implementation of design methodologies to support systematicdesign of optimised instances of these converters which combinemaximum performance with minimum power dissipation and

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elling of some major non-idealities that limit thephysical realisation of pipelined ADCs and the proposal, developmentand implementation of design methodologies to support systematicdesign of optimised instances of these converters which combinemaximum performance with minimum power dissipation and

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Introduction: Defining the Position of Non-Biological Complex Drugs,ed) NBCD-families are dealt with in 8 chapters of this book. As complex drug products request sophisticated analytical means for characterization of their structure and in vivo performance, ample attention is paid to the analytical challenges in two separate chapters. Finally, a perspective regardin

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Polymeric Micelles. Next, the pharmacology of polymeric micelles tested in the clinic is summarized and the relation between physicochemical characteristics and PK/PD as well as evaluation of choice and value of specific PK-parameters and required assay development are discussed. Regulatory aspects will be discussed

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GlatiramoidsCopaxone. are unknown and the precise mechanisms of immunomodulatory activity responsible for its therapeutic efficacy are not entirely elucidated. The identity, quality, and consistency of a glatiramoid are inexorably linked to its own manufacturing process. Several manufacturers now market glatira

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Iron Carbohydrate Complexes: Characteristics and Regulatory Challengesption, distribution, metabolism, and excretion (ADME) profiles have to be investigated and defined by appropriate in vivo test systems. The “nanoparticular” properties are key to their specific disposition which also influences pharmacodynamics and therefore efficacy and safety..Sensitive biomarkers

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