Titlebook: Neuropsychiatric Disorders; An Integrative Appro M. Gerlach,Jürgen Deckert,E. Koutsilieri Conference proceedings 2007 Springer-Verlag Vienn

HPA533

Journal of Neural Transmission. Supplementahttp://image.papertrans.cn/n/image/664388.jpg

诱惑

展览

抚育

forestry

GOUGE

Limousine

Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain,estigated in rat brain sections. In most regions cold isatin (0.2 mM) significantly reduced [.H]isatin binding. In addition to isatin, the other endogenous oxidized indoles, 5-hydroxyoxindole and oxindole were effective in displacing [.H]isatin.

palliate

The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders,allele-specific degradation of disease-inducing mRNA and we review the literature in the field of siRNA and its application in animal models of neurodegenerative diseases, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Huntingtons disease (HD) and spinocerebellar ataxia (SCA1).

OASIS

Tyrosinase is not detected in human catecholaminergic neurons by immunohistochemistry and Western bd enzyme. Since tyrosinase mRNA is suggested to be expressed in the SN of mice and humans, we reinvestigated the expression of tyrosinase in the human SNc and the locus coeruleus at the protein level by immunohistochemistry and Western blot analysis, but could not detect tyrosinase in these brain regions.

保守

Animal models in neurodegenerative diseases,1) reproducing in animals the mutations seen in inherited forms of PD; 2) intoxicating animals with putative environmental toxins causing PD. In this review we discuss the advantages and the drawbacks in term of neuroproction of the currently used models.