Titlebook: Neuroepigenomics in Aging and Disease; Raul Delgado-Morales Book 2017 Springer International Publishing AG 2017 epigenomics.genomics.Neuro

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Silvia Bassi Ph.D.,Takshashila Tripathi Ph.D.,Alan Monziani,Francesca Di Leva Ph.D.,Marta Biagioli P

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MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndromeing protein 2 (MeCP2), through its ability to bind to methylated DNA, seems to be a major player in regulating such unusual organization. An important contribution to this uniqueness stems from the intrinsically disordered nature of this highly abundant chromosomal protein in neurons. Upon its bindi

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Rubinstein-Taybi Syndrome and Epigenetic Alterationsto severe mental retardation (Rubinstein and Taybi, Am J Dis Child 105:588–608, 1963, Hennekam et al., Am J Med Genet Suppl 6:56–64, 1990). RSTS is caused by de novo mutations in epigenetics-associated genes, including the cAMP response element-binding protein (CREBBP), the gene-encoding protein ref

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Eating Disorders and Epigenetics characterize EDs often arise through the activation of latent genetic potentials by environmental exposures, and epigenetic mechanisms are believed to link environmental exposures to gene expression. This chapter provides an overview of genetic factors acting in the etiology of EDs. It then provide

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Drug Addiction and Histone Code Alterationsin reward. Numerous genes are involved in this process, and persistent changes in gene expression coincide with epigenetic histone modifications and DNA methylation. Histone modifications are attractive regulatory mechanisms, which can encode complex environmental signals in the genome of postmitoti