Titlebook: Neurodegenerative Disorders: Loss of Function Through Gain of Function; Konrad Beyreuther,Yves Christen,Colin L. Masters Conference procee

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https://doi.org/10.1007/978-3-662-04399-8Alzheimer; Alzheimer‘s Disease; Huntingdon‘s Disease; amyloid precursor protein; amyotrophic lateral scl

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978-3-642-07448-6Springer-Verlag Berlin Heidelberg 2001

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Neurodegenerative Disorders: Loss of Function Through Gain of Function978-3-662-04399-8Series ISSN 0945-6066 Series E-ISSN 2196-310X

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Mechanisms of Motor Neuron Death in ALS,e most common form of adult motor neuron disease in humans, ALS typically initiates in middle to late life, leading to paralysis and death within three to five years. The disease usually begins asymmetrically in one limb, most commonly the leg, and then appears to spread to involve contiguous groups

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The Value of Transgenic Models for the Study of Neurodegenerative Diseases,d, chronic illnesses that are among the most challenging and devastating diseases in medicine (Becker et al. 1998; Burright et al. 1995; Cleveland 1999; Davies et al. 1997; Goedert et al. 1998; Hardy and Gwinn-Hardy 1998; Lin et al. 1999; Mangiarini et al. 1996; Price et al. 1998b; Robitaille et al.

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Pathogenesis and Mechanism of Cerebral Amyloidosis in APP Transgenic Mice,ellular deposition of amyloid in plaques and vessels. In an effort to study the impact of cerebral amyloidosis on neurodegeneration, we have shown that amyloid plaque formation in APP transgenic mice is accompanied by region-specific neuron loss, synaptic changes, alterations in the cholinergic syst