Titlebook: Necrotizing Soft Tissue Infections; Clinical and Pathoge Anna Norrby-Teglund,Mattias Svensson,Steinar Skred Book 2020 The Editor(s) (if app

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,Necrotizing Soft Tissue Infections: Case Reports, from the Clinician’s Perspectives,es of NSTI, based on the invasive microorganisms. The speed of development and associated clinical features differ markedly depending on the bacterial etiology. Early recognition, extensive surgical debridement, and appropriate antimicrobials are pivotal for successful management. In this chapter, w

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Necrotizing Soft-Tissue Infections: Clinical Features and Diagnostic Aspects,STI is diagnosed by surgical exploration, where necrosis of the subcutaneous tissue and/or muscle tissue, undermining of the skin, thrombosis of the superficial veins, and deliquescent tissue can be seen. Patients can present with vague symptoms, and approximately half of patients experience severe

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Beta-Hemolytic Streptococci and Necrotizing Soft Tissue Infections, . (SD) have also been reported. In the INFECT cohort of 409 NSTIs patients, more than a third of the cases were caused by GAS (31%) or SD (7%). Risk factors of streptococcal NSTIs compared to streptococcal cellulitis have previously been largely unknown. The INFECT study confirmed blunt trauma as a

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Treatment of Necrotizing Soft Tissue Infections: Antibiotics,tion of potent antimicrobial agents is pivotal, but inadequate empirical therapy is unfortunately common. Optimization of the antibiotic treatment strategy in NSTIs requires consideration of local epidemiology of causative pathogens and antimicrobial resistance patterns, knowledge on common pathogen

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Pathogenic Mechanisms of Streptococcal Necrotizing Soft Tissue Infections,cularly . (group A streptococci (GAS)) but also . (SDSE, most group G and C streptococcus), are the main causative agents of monomicrobial NSTIs and certain types, such as .1 and .3, are over-represented in NSTI cases. An arsenal of bacterial virulence factors contribute to disease pathogenesis, whi

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Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infectns. Infections caused by group A streptococcus (GAS, .) are heterogeneous ranging from mild pharyngitis to severe invasive necrotizing fasciitis, a subgroup of necrotizing soft-tissue infections (NSTIs). While several strains of mice including BALB/c, C3H/HeN, CBA/J, and C57BL/10 offered significant

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Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections,CT study was designed to obtain such insights through the integration of patient data and results from different clinically relevant experimental models by use of systems biology approaches. This chapter describes the current state of biomarkers in NSTI and how biomarkers are categorized. We introdu

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