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Titlebook: Necrotic Cell Death; Han-Ming Shen,Peter Vandenabeele Book 2014 Springer Science+Business Media New York 2014 Apoptosis.Cell death.Necrosi

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书目名称Necrotic Cell Death
编辑Han-Ming Shen,Peter Vandenabeele
视频video
概述Examines several forms of necrotic cell death, including necroptosis, autophagic cell death, and PARP-mediated cell death.Discusses the effect of necrotic cell death on metabolism, inflammation, immun
丛书名称Cell Death in Biology and Diseases
图书封面Titlebook: Necrotic Cell Death;  Han-Ming Shen,Peter Vandenabeele Book 2014 Springer Science+Business Media New York 2014 Apoptosis.Cell death.Necrosi
描述Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.
出版日期Book 2014
关键词Apoptosis; Cell death; Necrosis; Necrotic cell death; Oxidative stress; Cell Cycle Analysis
版次1
doihttps://doi.org/10.1007/978-1-4614-8220-8
isbn_softcover978-1-4939-4402-6
isbn_ebook978-1-4614-8220-8Series ISSN 2625-2902 Series E-ISSN 2625-2899
issn_series 2625-2902
copyrightSpringer Science+Business Media New York 2014
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RIP1-Mediated Signaling Pathways in Cell Survival and Death Control,ular stresses such as DNA damage, RIP1 can transduce either pro-survival or pro-death signals. Thus, RIP1 plays a pivotal role in the decision of cells’ fate. In this chapter, recent reports on RIP1-mediated cell signaling with a focus on cell survival and death control will be summarized.
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Autophagic Cell Death: A Real Killer, an Accomplice, or an Innocent Bystander?,tudy of ACD, aiming to achieve a better understanding whether autophagy is a real killer, an accomplice, or just an innocent bystander in the course of cell death. Moreover, we describe ACD in lower eukaryotes and invertebrates such as . and .. Finally, we discuss the physiological or pathological relevance of ACD to human health and disease.
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Programmed Necrosis in Immunity and Inflammatory Diseases,nce suggests that programmed necrosis is also involved in bacterial infections and may even directly regulate inflammatory cytokine expression. In this chapter, we discuss how the RIP kinases contribute to different inflammatory diseases.
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