Titlebook: Natural Compounds as Drugs, Volume I; Frank Petersen,René Amstutz Book 2008 Birkhäuser Basel 2008 chemical space.drug research.enzymes.hig

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mastoid-bone

Drug discovery and development with plant-derived compounds,inical development. Therapeutic areas covered include cancer, viral infections including HIV, malaria, inflammatory diseases, nociception and vaccine adjuvants, metabolic disorders, and neurodegenerative diseases. Aspects which are specific to plant-based drug discovery and development are also addr

Cosmopolitan

过于平凡

Biodiversity, chemical diversity and drug discovery,uggest that there must remain many interesting natural molecules with potential therapeutic application yet to be discovered. Any efforts to successfully exploit the chemical diversity of microbial secondary metabolites need to rely heavily on a good understanding of microbial diversity, being the w

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plasma

Virtual screening for the discovery of bioactive natural products,g number of secondary metabolites and a growing number of molecular targets relevant in the therapy of human disorders, the huge amount of information needs to be handled. Virtual screening filtering experiments already showed great promise for dealing with large libraries of potential bioactive mol

Cardiac-Output

Strain improvement for production of pharmaceuticals and other microbial metabolites by fermentationy amounts of these secondary metabolic products as a matter of survival. Thus, these metabolites are not overproduced in nature, but they must be overproduced in the pharmaceutical industry. Genetic manipulations are used in industry to obtain strains that produce hundreds or thousands of times mor

GRATE

Nutritional and engineering aspects of microbial process development,effort had to be put in to develop commercially viable processes. A key part of this endeavor was the studies of the nutritional and the engineering parameters. In this chapter, the basic principles of optimizing the nutritional and engineering aspect of the production process are described with app

单调性

Natural products from plant cell cultures,ey role in human medicine. However, plants typically produce these compounds in low quantities, and harvesting plant natural products is frequently expensive, time-consuming and environmentally damaging. Plant cell culture provides a renewable, easily scalable source of plant material. In this chapt

hermitage

transferable features.All the authors have been active in th.Education is a universal priority. Currently, it is at a crossroad. In every society it is valued as a major road to produce more productive, more harmonious and healthier citizens. Yet, in every setting there is deep dissatisfaction with