Titlebook: Nanoscale Imaging of Synapses; New Concepts and Opp U. Valentin Nägerl,Antoine Triller Book 2014 Springer Science+Business Media New York 2

Lament

Imaging Signaling Transduction in Single Dendritic Spines,eds of protein species. As synaptic plasticity is caused by signaling coordinated differentially in space and time, understanding how the various proteins differ in their spatial and temporal signaling profiles is key to our understanding of synaptic plasticity as a whole. However, acquiring such in

Brain-Imaging

Imaging-Based Measures of Synaptic Tenacity,tional properties of neuronal networks, possibly providing the basis for phenomena collectively referred to as “learning and memory.” This belief has an important corollary: It implies that synapses, when . driven to change their characteristics by physiologically relevant stimuli, should retain the

CRACK

Zooming in on the (Peri)synaptic Extracellular Matrix,e diverse forms of the ECM. The most conspicuous aggregates of ECM molecules, containing chondroitin sulfate proteoglycans, hyaluronic acid, link proteins, and tenascin-R, are found around perisomatic GABAergic synapses on fast-spiking interneurons. However, also the perisynaptic extracellular space

Demulcent

Two-Photon Excitation STED Microscopy for Imaging Synapses and Glia in Acute Brain Slices,f living cells with a spatial resolution well below 100 nm, even down to a few nanometers. By breaking the classical diffraction barrier of optical microscopy, it offers the chance to close the gap in spatial resolution between electron microscopy and conventional light microscopy and is attracting

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