Titlebook: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens; A Novel NMR-Tool for Martin Lorenz St

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书目名称NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens影响因子(影响力)




书目名称NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens影响因子(影响力)学科排名




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2190-5053 iological dimensions of proteasome inhibitors.Includes supplMartin Stein‘s thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in

Flinch

Discussion,NMR-based nature of the assay, it is not prone to common artefacts caused by quenching or autofluorescence that are responsible for the plenitude of false positive and equally negative results in high-throughput screenings conducted with UV-VIS assays.

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Introduction,The ubiquitin-proteasome system (UPS) is responsible for the directed disposal of unfolded, misfolded and short-lived proteins in eukaryotic cells and is therefore a key player in protein homeostasis. Moreover, it participates in crucial biological pathways by the degradation of signaling factors such as cyclins or the tumor suppressor p53.

Surgeon

Objective,Due to the silencing of many natural toxins under common growth conditions, a robust and unambiguous technique is required to screen different fermentation approaches and identify the defined molecular trigger for the secretion of metabolites that affect biological maintenance.

药物

Materials and Methods,All applied compounds were acquired from the following companies: Bachem (Bubendorf, SWI), Enzo Life Sciences (Lörrach, GER), Fluka (Neu-Ulm, GER), Merck (Darmstadt, GER), Santa Cruz (Heidelberg, GER), Sigma-Aldrich (Steinheim, GER), Roth (Karlsruhe, GER) and VWR (Darmstadt, GER).

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978-3-319-38399-6Springer International Publishing Switzerland 2014