Titlebook: Microsystem Technology in Chemistry and Life Sciences; Andreas Manz,Holger Becker Book 1998 Springer-Verlag Berlin Heidelberg 1998 biology

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Micro Total Analysis Systems: Microfluidic Aspects, Integration Concept and Applications,ricated components for fluid handling is given. A description of the importance of sampling- and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realizat

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Integrated Chip-Based Microcolumn Separation Systems,ation technology has stimulated considerable research activity over the past five years. In addition, these devices hold the promise of being extremely rugged, capable of analysis of very small sample volumes, and suitable for high-throughput analysis through parallel sample processing. The goal of

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Biological Application of Microstructures,field of research and has found its first biotechnological and medical uses. This chapter contains selected examples of three-dimensional structures to characterise, manipulate and separate suspended and adherently growing cells. It addresses the problem of cell cultivation in strong electric fields

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Polynucleotide Arrays for Genetic Sequence Analysis,ay synthesis, as well as array packaging, sample preparation, array hybridization, epifluorescence confocal scanning, and data analysis are described. Applications to discovery, genotyping, expression, and resquencing are presented.

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Sensor Systems,be added creating whole microanalytical devices on chip. However, there are drawbacks involving inappropriate sensor function in media and production.Using sophisticated sensor construction and microfluidics such drawbacks can be overcome. In this chapter different sensor systems and whole microanal

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Sample Preparation In Microstructured Devices,f transfer devices, loss by evaporation, loss of components of the sample during manipulation and processing, and obtaining a representative sample from an nonhomogeneous specimen. A further difficulty is that the expected concentration of the analyte restricts the scale of miniaturization of the sa

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