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Titlebook: Microsurgical Models in Rats for Transplantation Research; Arnulf Thiede,Eberhard Deltz,Horst Hamelmann Conference proceedings 1985 Spring

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书目名称Microsurgical Models in Rats for Transplantation Research
编辑Arnulf Thiede,Eberhard Deltz,Horst Hamelmann
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图书封面Titlebook: Microsurgical Models in Rats for Transplantation Research;  Arnulf Thiede,Eberhard Deltz,Horst Hamelmann Conference proceedings 1985 Spring
描述Preclinical experimental transplantation research that is based on microsurgical models in rats fulfills two indispensable conditions for modern organ transplanta­ tion research: Almost all organ grafts can be performed on the rat with an amount of technical effort that is still justifiable. Thus transplantation models that are analogous to human organ transplantation can be developed, tested, and evaluated. This fulfills a necessary condition from the standpoint of surgery. With the species rat, we have a great variety of genetically different inbred strains. From the immunological point of view this is an indispensable prerequisite for the investigation of preclinical transplantation models that can be expected to produce controllable, reproducible results. In vivo experimental results can be supplemented by and correlated to in vitro tests. Lately these experimental results are being greatly expanded and more precisely defined by the application of immunohistological methods that have been established recently in Kiel. In this book we hope to present a cross section of the microsurgical models in use today and of current immunological and immunohistological models. Furthermore,
出版日期Conference proceedings 1985
关键词development; histology; immunology; microsurgery; organ; organ transplantation; pathology; reconstructive s
版次1
doihttps://doi.org/10.1007/978-3-642-61657-0
isbn_softcover978-3-642-64899-1
isbn_ebook978-3-642-61657-0
copyrightSpringer-Verlag Berlin, Heidelberg 1985
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Microsurgical Technique for Small-Intestine TransplantationSince in small-intestine transplantation many problems remain unsolved (see Hardy et al., this volume, p. 135), different experimental settings for small-bowel grafting are necessary. In the rat model several operative procedures are possible.
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https://doi.org/10.1007/978-3-642-61657-0development; histology; immunology; microsurgery; organ; organ transplantation; pathology; reconstructive s
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Reflections on the Requirements and Perspectives of a Microsurgical Research Groupists with the motivation to work. Of equal importance, however, is a mentor who will stimulate the team to long-lasting and productive cooperation. For 10 years we have considered Sun Lee, who is known as the father of rat microsurgery, as our mentor (Fisher and Lee 1965; Lee and Fisher 1961; Lee 1967; Lee and Orloff 1979).
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Technique for Orthotopic Rat Liver Transplantation technique for orthotopic rat liver transplantation could be presented (Lee et al. 1973). This technique, however, required a portosystemic shunt and was a difficult operation. To my knowledge, nobody, except its inventors, was able to reproduce the results.
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Microstructure of Allogeneic Lymph Vessel Transplants in the Ratssel defects by autogeneic grafts, Baumeister (1983) has performed 21 lymph vessel transplantations to date, mostly in women suffering from secondary lymphedema after mastectomy and postoperative irradiation. During on observation period of 5 months, an average reduction of 60% of the lymphedema was seen.
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