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Titlebook: Microbial DNA and Host Immunity; Eyal Raz Book 2002 Springer Science+Business Media New York 2002 Antigen.Asthma.DNA.HIV.Nucleotide.infect

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发表于 2025-3-21 16:10:10 | 显示全部楼层 |阅读模式
书目名称Microbial DNA and Host Immunity
编辑Eyal Raz
视频video
概述Includes supplementary material:
图书封面Titlebook: Microbial DNA and Host Immunity;  Eyal Raz Book 2002 Springer Science+Business Media New York 2002 Antigen.Asthma.DNA.HIV.Nucleotide.infect
描述Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider theapplications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
出版日期Book 2002
关键词Antigen; Asthma; DNA; HIV; Nucleotide; infections; infectious disease
版次1
doihttps://doi.org/10.1007/978-1-59259-305-7
isbn_softcover978-1-4684-9728-1
isbn_ebook978-1-59259-305-7
copyrightSpringer Science+Business Media New York 2002
The information of publication is updating

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Signal Transduction Pathways Activated By CpG-DNArrays of ODNs—there is a clear species specificity in respect to the sequences active in mouse vs humans. Hence, it might be speculated that double-stranded bacterial DNA represents a pool of various stimulatory sequences that are recognized by specific but species-dependent receptor systems. DNA th
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A Novel Toll-Like Receptor that Recognizes Bacterial DNAn with leucine-rich repeats in the extracellular domain and a cytoplasmic Toll/interleukin (IL)-1 receptor homology (TIR) domain. So far, ten members of human TLR are identified (.). Biological functions of some TLR family members are revealed; TLR4 is responsible for the recognition of LPS and TLR2
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Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpGy one of the nonbridging oxygens of the phosphate group is converted to sulfur. Phosphorothioates are poor substrates for most cellular nucleases. CpG PS-ODN display many of the activities of bacterial DNA, but owing to evidence of phosphorothioate-specific activity, caution has been urged in their
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Cross-Priming of CD8+ T Cells by Immunostimulatory Sequence DNAtitis B virus surface antigen (.), and human immunodeficiency virus gp 120 (.). Effective CTL and T. 1 priming has been observed with both intradermal (.) and intranasal (.) routes of immunization. Of note, priming of CTL activity with ISS-ODN and protein antigen, either coadministration or as conju
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Immunostimulatory DNA Sequence Based Mucosal Vaccinesstimulating protective mucosal immune responses. Live viral vaccines, such as the attenuated oral polio vaccine, induce strong mucosal immune responses. However, only a limited number of attenuated vaccines exist. The majority used in clinical practice are derived from recombinant proteins (.). Thes
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