Titlebook: Microbial Cyclic Di-Nucleotide Signaling; Shan-Ho Chou,Nicolas Guiliani,Ute Römling Book 2020 Springer Nature Switzerland AG 2020 Microbio

Favorable

Structure and Regulation of EAL Domain Proteinsgulation and has provided novel insight into the enzymatic reaction mechanism. Several regulatory layers may control activity, including dimerisation, active site formation, and metal coordination. In this review, we provide a concise summary of these exciting findings and highlight open research qu

出血

软弱

Structure and Function of HD-GYP Phosphodiesterasesred into two distinct groups depending on the metal binding site, which can accommodate two or three metal ions. The nature and the number of bound metals determine whether a certain HD-GYP will be active as a PDE or will function as a dinucleotide binding domain. In this chapter, we will review the

LOPE

A Unified Catalytic Mechanism for Cyclic di-NMP Hydrolysis by DHH–DHHA1 Phosphodiesterasesears. According to detailed structural and enzymatic analyses, we have summarized a unified molecular mechanism for the DHH–DHHA1 PDEs and systematically analyzed the catalytic activities of DHH–DHHA1 PDEs on other cyclic di-NMPs (cyclic di-GMP and cGAMP).

切割

固执点好

Detection of Cyclic Dinucleotide Binding Proteinss, the field has revealed that cyclic di-GMP directly regulates many cellular functions through allosteric binding. Despite the success in the field of identifying protein receptors in the past few decades, cyclic dinucleotide receptors often can only be experimentally identified due to their divers

Silent-Ischemia

生存环境

Metabolic Regulation by Cyclic di-AMP Signalingonal levels, as well as the molecular mechanism of this regulation. We will highlight the regulation of central carbon metabolism through pyruvate carboxylase, the regulation of cell wall metabolism through the . riboswitch, and the impact on host cell inflammatory response through competitive inhib

synchronous

Transfusion

Activation of Bacterial Cellulose Biosynthesis by Cyclic di-GMPtructural and functional characterizations of . cellulose synthase in resting and activated states provided unique insights into how cyclic di-GMP modulates enzymatic functions. This will be reviewed by discussing (1) biochemical analyses leading to cyclic di-GMP’s discovery and elucidation of its a