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Titlebook: Metastatic Bone Disease; Fundamental and Clin Ingo J. Diel,M. Kaufmann,G. Bastert Conference proceedings 1994 Springer-Verlag Berlin Heidel

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978-3-540-57356-2Springer-Verlag Berlin Heidelberg 1994
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Bisphosphonates: Mechanisms of Action and Clinical Use in Hypercalcemia of Malignancy and Tumor-IndThe bisphosphonates are a new class of drugs which have been developed in the past two decades for use in various diseases of bone, tooth, and calcium metabolism. This review covers the chemistry, the mechanisms of action, and the clinical application of these compounds in tumor-induced bone disease and hypercalcemia.
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Incidence and Distribution of Bone Metastases, from 1980 for the European Community countries estimate 1 220 000 incident cases of cancer and 750 000 deaths. Death from cancer is usually due to the development of metastases, and the skeleton is the organ most frequently involved.
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Historical Remarks on Metastasis and Metastatic Bone Disease,’s perspective is the radical evolution in the basic concept of metastasis. And because the concept has evolved with developments and discoveries outside the specific area of oncology, historical theories about metastasis must be seen in the context of advances in medical science in general: from hu
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Nature of Metastatic Bone Disease,s common. The high frequency of carcinomas of the breast, bronchus and prostate probably makes these cancers account for more than 80% of the incidence of metastatic bone disease. The distribution of bone metastases is predominantly to the axial skeleton, particularly the spine, pelvis and ribs, rat
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Incidence and Distribution of Bone Metastases, from 1980 for the European Community countries estimate 1 220 000 incident cases of cancer and 750 000 deaths. Death from cancer is usually due to the development of metastases, and the skeleton is the organ most frequently involved.
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Normal Bone Remodeling and Metastatic Bone Disease,ytic or sclerotic lesions since the tumor cells stimulate resident bone cells to cause excessive local resorption or new bone formation. This local stimulation of osteoclasts or osteoblasts takes place on a background of normal bone remodeling which is under the control of factors released locally i
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Morphological Findings in Bone Metastasis, Tumorosteopathy and Antiosteolytic Therapy, lung and liver. Bone metastases are in fact metastases of the bone marrow, and the term bone metastasis — although it has been used since the beginning of clinical interest in this subject — is therefore incorrect. The tumor cells growing in the bone marrow can disturb skeletal and calcium homeosta
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