Titlebook: Metal Ions in Gene Regulation; Simon Silver,William Walden Book 1998 Springer Science+Business Media Dordrecht 1998 Escherichia coli.Regul

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Itinerant

Mechanisms for Induction and Rerepression of Ferritin Synthesisors and Hentze (1993), Klausner et al. (1993), Munro (1993), Theil (1993)]. Messages that contain functional IREs in their 5′ UTRs code for ferritin (Leibold and Guo 1992; Melefors and Hentze 1993; Klausner et al. 1993; Munro 1993; Theil 1993), erythroid δ-aminolevulinic acid synthase (δ-ALAS) (Cox

Oligarchy

Metallothionein Gene Regulation in Mouse Cellsrocedure, we found that a nuclear protein of 108 kDa, termed MEP-1, specifically binds to the different MRE elements of the mouse . gene promoter. MEP-1 has been purified, and footprinting studies demonstrated that purified MEP-1 specifically binds to MRE sequences. MEP-1 binding activity is also in

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Menkes’ and Wilson’s Diseases: Genetic Disorders of Copper Transport978). All organisms must have developed mechanisms for supplying copper to essential enzymes without damaging cellular constituents. It is most probable that this delivery is achieved by maintaining the copper in a complex at all times. Thus the Cu ion must be transferred from one complex to another

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Metal Ion Stress in Yeasttions of low or high concentrations in the environment or diet can result in impaired physiology (Figure 11.1). Deficiency of an essential metal ion may impair physiology through loss of critical enzymatic functions of metalloenzymes. Excessive metal concentrations may affect cellular metabolism in

Introduction

The Molecular Biology of Iron and Zinc Uptake in ,tural stability. Examples include alkaline phosphatase, alcohol dehydrogenase, aspartate transcarbamoylase, carbonic anhydrase, and several proteases. Zinc is also an important component of enzymes involved in transcription and of accessory transcription factors, the zinc-finger proteins, that regul

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Metallothionein Gene Regulation in Cyanobacteria3; Erbe et al. 1995), and one metal-responsive .-acting factor (a repressor) has been cloned and characterized (Huckle et al. 1993; Morby et al. 1993). The mechanisms involved in metalloregulation of this cyanobacterial metallothionein gene, which clearly differ from those in eukaryotes, are describ

prodrome