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Titlebook: Membrane Transport Mechanism; 3D Structure and Bey Reinhard Krämer,Christine Ziegler Book 2014 Springer-Verlag Berlin Heidelberg 2014 Cryst

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书目名称Membrane Transport Mechanism
副标题3D Structure and Bey
编辑Reinhard Krämer,Christine Ziegler
视频video
概述Covers wide range of different membrane transporters.Links 3D structure to function.Written by international renowned experts
丛书名称Springer Series in Biophysics
图书封面Titlebook: Membrane Transport Mechanism; 3D Structure and Bey Reinhard Krämer,Christine Ziegler Book 2014 Springer-Verlag Berlin Heidelberg 2014 Cryst
描述.This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive pic
出版日期Book 2014
关键词Crystallography; Membrane transporters; Secondary transporters; Transport mechanism; Transporter protein
版次1
doihttps://doi.org/10.1007/978-3-642-53839-1
isbn_softcover978-3-662-52305-6
isbn_ebook978-3-642-53839-1Series ISSN 0932-2353 Series E-ISSN 1868-2561
issn_series 0932-2353
copyrightSpringer-Verlag Berlin Heidelberg 2014
The information of publication is updating

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0932-2353 ides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism
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Characterizing the Structure, Function, and Evolution of Human Solute Carrier (SLC) Transporters Usdrugs. In humans, there are about 400 SLC members, many of which are of medical importance. They can be drug target themselves (e.g., the serotonin transporter, SERT) or regulate the absorption, distribution, metabolism, and excretion (ADME) of drugs (e.g., the organic cation transporter 1, OCT-1).
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Structures of the Prokaryotic Galactose Transporter vSGLT and Their Implications on Alternating Acc comprise a large family of secondary active transporters fundamental to the homeostasis of a variety of solutes including sugars, inositols, anions, short chain fatty acids, choline, and vitamins. This chapter will explicate the structural framework of the sodium galactose transporter from . (vSGLT
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