Titlebook: Membrane Physiopathology; Ghassan Bkaily Book 1994 Springer Science+Business Media New York 1994 arterial hypertension.cardiovascular.hear

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Ionic Channels Involved in the Myocardial Response to Metabolic Stress,rodes in . hearts of guinea pigs and cats. These effects were accompanied by flattening of the plateau and were correlated with the shortening of the QT interval and the T wave alterations previously observed in human electrocardiograms. In 1954, Trautwein et al. (.) showed that intracellularly reco

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Role of Na/H Exchange and [Ca2+]i in Electrophysiological Responses to Acidosis and Realkalization the mechanisms responsible for the increase in [Ca.]. remain unclear (.). In this regard, since the intracellular pH is much lower than that of the perfusate during early reperfusion (.), a pH gradient develops instantaneously across the cardiac cell membrane. This pH gradient activates the sodium/h

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Cardiac Cell Lines: Electrophysiological Properties and Implications in Cardiac Disease,emistry, and myogenesis (.–.). Immortalized cell lines from dysgenic mouse skeletal muscle (.) may become excellent transient systems for expression of skeletal muscle calcium channels (.). Cardiac cell lines have been more difficult to obtain and to date only a small number has been thoroughly char

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Regulation of Ca2+ Channels in Vascular Smooth Muscle Cells by Cyclic Nucleotides and by G-Protein nd cGMP-dependent protein kinase (cG-PK) inhibit channel activity (reviewed in .). Phosphorylation by protein kinase C (PK-C) also stimulates activity of the myocardial slow Ca. channels (.). Intracellular ATP also modulates slow Ca. channel activity in myocardial cells, ATP being obligatory for cha

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Role of the R-Type Ca2+ Channel in Cardiovascular Physiopathology,uscle (VSM), at least two types of Ca. currents are present (., ., ., .–.); L-type (for long lasting), and T-type (for transient) (., ., .). Compared to the L-type Ca. current, the T-type current activates and inactivates relatively rapidly at more negative test potentials. The L-type Ca. channel in

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Pharmacology of the Human Precursors of Endothelin: Role of Functional Receptors and Endothelin-Connd paracrine organ. Indeed, the endothelial cell secretes numerous factors which importantly modulate the vascular tone as well as thrombogenesis. Chronologically, prostacyclin (PGI.) was the first reported autacoid generated from the endothelium (.), followed by the report on the “obligatory role o

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