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Titlebook: Mechanosensitivity of the Heart; Andre Kamkin,Irina Kiseleva Book 2010 Springer Science+Business Media B.V. 2010 Activation.Angiotensin II

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Effects of Applied Stretch on Native and Recombinant Cardiac Na+ Currentsr myocytes, (ii) studies of currents due to this Na. channel transcript expressed in a . oocyte preparation, and (iii) integration of these findings, following appropriate alterations of the descriptors for this Na. current in a mathematical model of the human ventricular action potential. The resul
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The Role of Mechanosensitive Fibroblasts in the Heart: Evidence from Acutely Isolated Single Cells, h in turn leads to hyperpolarization. Cultured cardiac fibroblasts preserve MGCs up to 5 days without special flexible substrates and possess electrophysiological properties of freshly isolated cells. Thus, cardiac fibroblasts function as mechano-electric transducers in the heart and represent the c
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The Contribution of MEF to Electrical Heterogeneity and Arrhythmogenesiss in these diseases. Here, we discuss the evidence that MEF is heterogeneous in the heart, in the same way that other electrophysiological properties are heterogeneous. The reasons why this may be are discussed. The possible role that this heterogeneity, and its modulation in some common cardiac dis
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Stretch-Induced Inotropy in Atrial and Ventricular Myocardiumre-incubation with angiotensin II or endothelin-1 attenuate the atrial SFR. In addition, stretch results in a large NHE-dependent [Na.]. increase in ventricle but only a small, NHE-independent [Na.]. increase in atrium. Stretch activated channels are not involved in the SFR in either tissue but cont
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Effects of Wall Stress on the Dynamics of Ventricular Fibrillation: A Computer Simulation Study of M prolongation of APD and extension of the refractory area in the wavetail. As left ventricular pressures increased, the stretched area became wider and the refractory area was further extended. The extended refractory area in the wavetail facilitated wave break-up and the meandering of tips through
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Jeffrey G. Jacot,Anna J. Raskin,Jeffrey H. Omens,Andrew D. McCulloch,Leslie Tung
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