Titlebook: Management of Early Stage Breast Cancer; Basics and Controver Beena Kunheri,D. K. Vijaykumar Book 2021 Springer Nature Singapore Pte Ltd. 2

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Adjuvant Chemotherapy in Early Breast Cancer,cteristics and tumour biology. For the same reason, decision on adjuvant chemotherapy is often difficult for the clinician. In luminal-like tumours, gene expression profiling is increasingly used to aid in deciding on adjuvant therapy. In HER2-positive tumours, all women with a tumour size of >1 cm

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Role of Anti-HER2/Neu Molecules in the Management of HER2-Positive Early Breast Cancer,ural history with poor response rates and decreased survival [1]. HER2-targeted therapies have changed this landscape as has been proven by an improvement in progression-free survival (PFS) and overall survival (OS) with the addition of trastuzumab as compared to chemotherapy in patients with early

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Role of Radiation Therapy in Early Breast Cancer Patients with One to Three Pathological Nodes,While the benefit of adjuvant radiation therapy has been well established, for most patient groups, a clinical entity that has eluded a definite categorization is the group of patients having one to three lymph nodes with pathologically confirmed tumour involvement. Over the course of this chapter,

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Regional Nodal Irradiation in Early Breast Cancer,y some investigators. The standard treatment of early-stage breast cancer is breast-conserving surgery followed by whole-breast irradiation with or without tumour bed boost. The term regional nodal irradiation refers to irradiation of the regional nodes, which include axillary nodes (levels I–III),

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Hypofractionation: Evidence, Rationale, and Practice,xcision and 5–6-week-long conventionally fractionated whole breast irradiation (WBI) and a tumor bed boost. Despite its proven efficacy, many patients forego radiation therapy or opt for mastectomy due to the inconvenience of its long duration. Hypofractionated WBI overcomes this limitation and is i

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