Titlebook: Malignant Brain Tumors; State-of-the-Art Tre Jennifer Moliterno Gunel,Joseph M Piepmeier,Joachi Book 2017 Springer International Publishing

fructose

CROAK

Fluorescence-Guided Resection of Malignant Gliomasgies utilizing induced tissue fluorescence for aiding discrimination have evolved into useful adjuncts. 5-Aminolevulinic acid (5-ALA) is the most highly investigated compound so far and approved for this purpose, inducing the selective accumulation of fluorescent porphyrins in malignant cells, which

Visual-Acuity

BAIT

Current Standard Treatment Options for Malignant Gliomagrade 4 glioblastoma. The current standard of care for newly diagnosed glioblastoma was established with the landmark findings of the EORTC-NCIC clinical trial which consists of six weeks of concurrent fractionated radiation therapy and temozolomide followed by 6 cycles of adjuvant temozolomide (Stu

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Targeting Aberrant Signaling Pathwaysadiation, and chemotherapy. The use of advanced sequencing technologies and large-scale gene expression studies has provided an in-depth description of the distinct molecular and genetic alterations in glioblastoma inspiring interest in the development of targeted therapies. Unfortunately, despite t

Constituent

Targeted Therapy of IDH1-Mutated Tumorsgenes encoding . and . have recently been found in glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. The mutant protein loses its normal enzymatic activity and gains a new ability to produce the ‘oncometabolite’ 2-hydroxyglutarate (R-2-HG). R-2-HG inhibits en

aggressor

Antiangiogenic Therapy for Malignant Gliomastionale that microvascular proliferation is a defining feature of these tumors, which also express high levels of proangiogenic factors such as vascular endothelial growth factor (VEGF). Despite promising preclinical data and early clinical trials, antiangiogenic agents have failed to show a surviva

Onerous

Immunotherapy for High-Grade Gliomasma is the most aggressive form and prognosis remains poor despite the current gold-standard first-line treatment—maximal safe resection and combination of radiotherapy with temozolomide chemotherapy—resulting in a median survival of approximately 15–17 months. Tumor recurrence occurs in virtually al

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Novel Delivery Strategies (BBB), drug efflux transporters, and the steric and physiologic constraints of the brain interstitium. Novel strategies for optimizing drug delivery to the CNS include the development of innovative carriers, such as nanoparticles, viral vectors, and stem cells. These drug vehicles may be delivered

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