Titlebook: Lymphoma and Leukemia of the Nervous System; Tracy Batchelor,Lisa M. DeAngelis Book 2012 Springer Science+Business Media, LLC 2012 Cancer.

Indigence

Biology of Primary Central Nervous System Lymphomaor this uncommon variant of extranodal non-Hodgkin lymphoma (NHL). An accumulating body of evidence suggests that the molecular pathogenesis of PCNSL is distinct from systemic lymphomas of the same histological type. First, 90% of NHL cases that present in the central nervous system (CNS) will, upon

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Chemotherapy for Primary Central Nervous System Lymphomas in this population. However, the standard regimens used for systemic NHL are ineffective in PCNSL due to inadequate blood brain barrier penetration. Methotrexate-based regimens are most commonly used, although the proportion of patients cured with this approach is low. Intrathecal chemotherapy for

Inexorable

High-Dose Chemotherapy and Stem Cell Transplantation for Primary CNS Lymphomat of these patients. First, it is important to define whether the lymphoma is confined to the CNS (primary CNS lymphoma, PCNSL) or whether there is co-existent or pre-existent systemic lymphoma (stage IV or secondary CNS lymphoma, respectively). Second, it is important to define the histological sub

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