Titlebook: Leptomeningeal Metastases; Lauren E. Abrey,Marc C. Chamberlain,Herbert H. Eng Book 2005 Springer-Verlag US 2005 Nervous System.anatomy.can

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Anatomy and Physiology of the Leptomeninges and CSF Space, system by cells of the choroid plexus and ependyma. This chapter describes in detail the normal anatomic structure and physiologic interactions of the cerebrospinal fluid and leptomeningeal space that are critical to our understanding and treatment of leptomeningeal metastases.

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Leptomeningeal Metastasis of Primary Central Nervous System (CNS) Neoplasms,cell tumors, and primary CNS lymphoma, seeding of the cerebrospinal fluid space is a critical factor in determining stage, prognosis and appropriate therapy. Other tumor types, such as glioma, may have radiographic evidence of leptomeningeal metastases without clear impact on prognosis or therapy.

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Leptomeningeal Cancer in the Pediatric Patient,wever, the treatment of other leptomeningeal cancers has been less successful and the neurologic morbidity associated with central nervous system-directed therapy has a significant long-term impact on quality of life. Further research is critical to identify new therapeutic strategies for children with or at high risk for leptomeningeal cancer.

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Current Treatment of Leptomeningeal Metastases: Systemic Chemotherapy, Intrathecal Chemotherapy andhe majority of patients have widespread incurable systemic tumor, treatment is predominantly palliative; however, some patients with leukemia, lymphoma or breast cancer may have prolonged remissions and the possibility of cure.

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Improving the Outcome of Patients with Leptomeningeal Cancer: New Clinical Trials and Experimental are being developed to target the cerebrospinal space. These include new intrathecal formulations of systemic chemotherapy as well as the development of radiolabeled immunoconjugates and antitumor antibodies. Furthermore, there is debate as to the optimal strategy of drug delivery for leptomeningeal tumor.

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Leptomeningeal Metastases from Solid Tumors (Meningeal Carcinomatosis),n limited. Radiotherapy is used to treat bulky tumor and provide symptomatic relief. Intrathecal chemotherapy benefits a selected subset of patients. The challenge to the future is to delineate the molecular mechanisms underlying LM and to develop novel therapeutic or prophylactic modalities to combat LM.

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Leptomeningeal Metastases from Leukemias and Lymphomas, crucial and prophylactic therapy of the CSF compartment is required. Furthermore, while the overall prognosis for patients with leptomeningeal metastases from leukemia and lymphoma is similar to solid tumors, selected patients have excellent response to therapy and attain durable remission. Therefore, aggressive treatment is warranted.

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Neurosurgical Interventions for Leptomeningeal Tumor,will be presented. The aim will be to familiarize non-surgical providers with the indications for and complications associated with these neurosurgical procedures as a component of the adjuvant treatment of leptomeningeal disease.

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0927-3042 e-of-the-art therapy for the cancer patient with leptomeningeal cancer with additional information on epidemiology, symptom management, new clinical trials, and current basic research in animal models for experimental therapies.978-1-4614-9890-2978-0-387-24199-9Series ISSN 0927-3042 Series E-ISSN 2509-8497

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Leptomeningeal Neoplasia: Epidemiology, Clinical Presentation, CSF Analysis and Diagnostic Imaging,ystem prophylaxis. Regardless, both types of patients present with symptoms referrable to multiple levels of the central nervous system and a careful dignostic approach incorporating cerebrospinal fluid studies and appropriate neuroimaging is critical.