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Titlebook: Ion Flux in Pulmonary Vascular Control; E. Kenneth Weir,Joseph R. Hume,John T. Reeves Book 1993 Springer Science+Business Media New York 1

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发表于 2025-3-21 18:16:13 | 显示全部楼层 |阅读模式
书目名称Ion Flux in Pulmonary Vascular Control
编辑E. Kenneth Weir,Joseph R. Hume,John T. Reeves
视频video
丛书名称NATO Science Series A:
图书封面Titlebook: Ion Flux in Pulmonary Vascular Control;  E. Kenneth Weir,Joseph R. Hume,John T. Reeves Book 1993 Springer Science+Business Media New York 1
描述6 Ions can pass through a single membrane channel at a rate of 10 ions/second. Over the last decade the ability to measure ion flux so precisely and to document the opening and closing of individual ion channels has provided a powerful tool to those working on smooth muscle physiology and vascular reactivity. The use of potassium channel blockers by Tom Lloyd in the 1960s and calcium channel blockers by Ivan McMurtry in the 1970s indicated the importance of ion flux in regulating pulmonary vascular tone. Recent advances in technology. principally the patch-clamp technique and fluorescent ion-sensitive dyes. now permit a more detailed description of physiologic mechanisms. This volume arises from the Sixth Grover Conference on the Pulmonary Circulation. a NATO Advanced Research Workshop. held in Colorado in October 1992. A group of international sCientists who are leaders in the field of ion flux focused their attention on the problems of the pulmonary vasculature. The chapters in this book describe the present state of knowledge of the movement and storage of ions in vascular endothelial and smooth muscle cells. Those who are not familiar with the techniques of patch clamping and c
出版日期Book 1993
关键词ATP; ATPase; Calcium; calcium channels; cells; cyclin; endothelium; smooth muscle
版次1
doihttps://doi.org/10.1007/978-1-4615-2397-0
isbn_softcover978-1-4613-6016-2
isbn_ebook978-1-4615-2397-0
copyrightSpringer Science+Business Media New York 1993
The information of publication is updating

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发表于 2025-3-21 23:07:18 | 显示全部楼层
Influence of Physical and Environmental Factors on Ion Channels in Arterial Musclefor the transduction of physical and environmental influences with respect to vascular reactivity is activation or inhibition of ion conductance systems setting a level of membrane potential around which vascular tone is enhanced or reduced.
发表于 2025-3-22 04:19:05 | 显示全部楼层
An ATP-Activated Potassium Channel in Smooth Muscle Cells from the Pulmonary Arteryoreceptors, so experiments on single smooth muscle cells from pulmonary vessels, backed up by complementary experiments on isolated vessels and lungs, are likely to be the most successful way forward.
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Role of Calcium ATPases in Pulmonary Vascular Reactivity: plasma membrane (PM) Ca. pumps (130–150 kd) and sarcoplasmic or endoplasmic reticulum (SER) Ca. pumps (100–115 kd) (12, 16, 17). The PM Ca. pumps along with Na./Ca. exchange are the major mechanisms for Ca. extrusion from the cell. The SER Ca.-ATPase pumps buffer an increase in [Ca.]. by reloading intracellular stores with Ca. (16, 36).
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Calcium Channels in Arterial Smooth Muscle Cellstrongly suggest that calcium entry through dihydropyridine-sensitive calcium channels is necessary for maintained tone development in many cases, and that the membrane potential dependence of arterial tone arises from the voltage-dependence of the calcium channel (12).
发表于 2025-3-23 06:50:09 | 显示全部楼层
sely and to document the opening and closing of individual ion channels has provided a powerful tool to those working on smooth muscle physiology and vascular reactivity. The use of potassium channel blockers by Tom Lloyd in the 1960s and calcium channel blockers by Ivan McMurtry in the 1970s indica
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