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Titlebook: Intractable Seizures; Diagnosis, Treatment W. McIntyre Burnham,Peter L. Carlen,Paul A. Hwang Book 2002 The Editor(s) (if applicable) and Th

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Intractable Seizures978-1-4615-1335-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
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Surgery for West’s SyndromeWest’s syndrome or “infantile spasms” is named after a physician by the name of West, who wrote a letter to Lancet in 1841 in which he described a “peculiar form of convulsion” associated with mental retardation as seen in his son. Clinically, West’s syndrome consists of a triad of myoclonic spasms, hypsarrhythmic EEG and mental retardation.
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Pathophysiology of Infantile SpasmsRecent observations have contributed significantly to our understanding of the pathophysiology of infantile spasms, and have allowed a number of hypotheses to be generated. Any consideration of the pathophysiology of infantile spasms must take into account the following features common to the population of subjects with infantile spasms:
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Neural Growth, Neural Damage and Neurotrophins in the Kindling Model of Epilepsy, there are a wide variety of clinical events that are suitably modeled by kindling phenomena. We will begin with a brief description of some of these phenomena. Readers familiar with kindling may wish to jump ahead to the section on .
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