Titlebook: Intrabodies; Basic Research and C Wayne A. Marasco Book 1998 Springer-Verlag Berlin Heidelberg 1998 AIDS.Antikörper.Gentherapie.Interleukin

LEVER

Gene Therapy for HIV-1 Using Intracellular Antibodies Against HIV-1 Gag Proteins,he therapeutic gene in cells for the treatment of the disease. When considering HIV-1 infection, genetic alteration of the host cell could potentially confer permanent suppression of viral replication after infection, or protection against viral infection.

纹章

Designing Intrabodies: Structural Features and the Use of Intracellular Trafficking Signals,rotein or nucleic acid, carbohydrate or lipid. The basic principle behind intrabodies is a marriage between an antibody binding site and the molecular instructions to direct this binding site to a precise intracellular location. By harvesting the power and diversity of the immune system in the form

reserve

Phage Libraries for Generation of Single Chain Fv Antibodies for Intracellular Immunization, them useful tools for the in situ analysis of intracellular molecules. Antibodies can be directly introduced into the cell or they can be expressed from their genes in a specific cellular compartment where they will bind their target. The introduction of antibodies intracellularly was first success

随意

,Phenotypic Knockout of the Human Interleukin-2 Receptor α Chain on Primary and HTLV-I Transformed T T cells.. Two functional forms of IL-2 receptor have been identified and are distinguished by their subunit compositions and affinities for IL-2 (Table 3.1) . The high-affinity receptor (K. 10. M) present on activated T cells is composed of α, β and γ chains. Quiescent T lymphocytes and natural kil

婴儿

FELON

Intracellular Antibody-Mediated Knockout of the ErbB-2 Oncoprotein as a Cancer Gene Therapy Approac lesions associated with malignant transformation and progression are being identified. The recognition of, and definition of, the molecular basis of carcinogenesis makes it rational to consider genetic approaches to therapy. In this regard, a number of strategies have been developed to accomplish c

记忆法

纺织品

Intrabodies Against the HIV-1 Regulatory Proteins: Tat and Rev as Targets for Gene Therapy,be. For example, in India, researchers estimate that by the year 2000 anywhere from 15–50 million people could be HIV positive. Half the prostitutes in Bombay are already infected and doctors report that the disease is spreading along major truck routes and rural areas, as migrant workers bring the

saphenous-vein

Gene Therapy for HIV-1 Using Intracellular Antibodies Against HIV-1 Gag Proteins,unology Syndrome (AIDS).. AIDS develops after a long incubation period of the virus, resulting in immunologic disorders and neurological disease.. The inability to control the progress of HIV-1 infection with traditional therapies has compelled the medical community to search for alternative therapi

landmark