Titlebook: Intra-Arterial and Intracavitary Cancer Chemotherapy; Proceedings of the C Stephen B. Howell Conference proceedings 1984 Martinus Nijhoff P

AV-node

Phase I Trials and Pharmacokinetic Studies of Intraperitoneal Cisplatin, Melphalan, Methotrexate, an the UCSD Cancer Center. For all four agents, there is a very large pharmacologic advantage to administration via the intraperitoneal route. The mean ratio of total drug exposure for the peritoneal cavity to plasma was 12.4 (range 2.9–37.4) for cisplatin, 65 (range 17–176) for melphalan, 92 (range 7

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Clinical Pharmacology of Intraperitoneal (IP) Bolus Mitomycin C and Continuous IP Infusion 5-Fluorouin other cancers as well. The pharmacokinetic rationale for IP injection of antineoplastic drugs has been delineated by Dedrick et al..) At steady state, the selective advantage (R.) of a direct drug infusion into the peritoneal cavity relates directly to the total body clearance (TBC) of the drug i

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ineluctable

Intravesical Doxorubicin for Prophylaxis in the Management of Recurrent Superficial Bladder Carcinome. The 5-year survival rates range between 65 and 85 per cent. However, 5 0 to 70 per cent of the patients will have recurrent lesions of a similar or different stage or grade (1). In a detailed natural history study by the National Bladder Cancer Collaborative Group A, 30 per cent of the patients w

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Medical Principles of Intraperitoneal and Intrapleural Chemotherapypproach to the management of malignant disease principally confined to the peritoneal or pleural cavities. The importance of establishing a safe and simple method of accessing the abdominal cavity has been discussed in another paper in this symposium.

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Management, Complications, and Evaluation of Intra-arterial Infusionstem itself. In addition, as one would anticipate from a regionally focused treatment, the major toxicities of intra-arterial treatment are regional in nature. This chapter will briefly review the major unique considerations with intra-arterial chemotherapy as commonly practiced.

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