Titlebook: Intra-Arterial and Intracavitary Cancer Chemotherapy; Proceedings of the C Stephen B. Howell Conference proceedings 1984 Martinus Nijhoff P

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Management, Complications, and Evaluation of Intra-arterial Infusions consideration is the need for a drug delivery system capable of infusing selected small arteries. Recent interest in intra-arterial chemotherapy has stemmed indirectly, in large part, from recent advances in drug delivery systems and monitoring, rather than from the discovery of new agents that are

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Pharmacokinetic Rationale for Intracavitary Therapyexperimental results. Other presentations will focus on the clinical and pharmacokinetic results of intracavitary trials, so I’ll focus mainly on the background and theory. In particular, I have been asked to cover those pharmacokinetic factors which led to the pursuit of intracavitary therapy.

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Intra-arterial Therapy of Hepatic Metastasestial (Table 1). Recent developments have defined the prerequisites for successful hepatic arterial chemotherapy and provided the methods for achieving those prerequisites (Table 2).. The development of the totally implanted drug delivery system, its successful application in several large phase II s

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Intra-arterial vs Intravenous FUDR for Colorectal Cancer Metastatic to the Liver: A Northern Califorpatic arterial embolization or ligation have low response rates; few patients are eligible for partial hepatectomy to eradicate anatomically limited disease; and the role of liver-directed therapy with drugs in patients with metastases confined to the liver remains uncertain.

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Randomized Study of Intrahepatic vs Systemic Infusion of Fluorodeoxyuridine in Patients with Liver M of patients with colorectal carcinoma develop liver metastases during the course of their illness ,. and 30% will have hepatic metastases as the only site of disease .. The average response rate of metastatic colon cancer to traditional bolus 5-FU is around 20%.. The response rate is approximately

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The Rationale and Methodology for Intra-arterial Chemotherapy with BCNU as Treatment for Glioblastomandard therapy for post-operative glioblastoma in at least five institutions. The approach allows for five-fold multiples of drug into localized intracerebral tumor without increasing systemic toxicity. Major complications are limited to ipsilateral eye pain and diminished acuity treated with system

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Intra-arterial Cis-Platinum in Advanced Solid Tumorsdex. Initially, efforts were directed toward reducing toxicity. Dose-limiting nephrotoxicity has been successfully ameliorated by a variety of hydration schema including mannitol diuresis, sodium thio- sulfate administration and the use of hypertonic saline.. Severe nausea and vomiting have been avo

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