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Titlebook: Intestinal Tumorigenesis; Mechanisms of Develo Vincent W. Yang,Agnieszka B. Bialkowska Book 2015 Springer International Publishing Switzerl

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发表于 2025-3-21 19:04:13 | 显示全部楼层 |阅读模式
书目名称Intestinal Tumorigenesis
副标题Mechanisms of Develo
编辑Vincent W. Yang,Agnieszka B. Bialkowska
视频video
概述Provides in-depth review of recent developments in the field of intestinal tumorigenesis.Covers the role of signaling pathways, epigenetics and stem cells.Gives latest targeted therapies for intestina
图书封面Titlebook: Intestinal Tumorigenesis; Mechanisms of Develo Vincent W. Yang,Agnieszka B. Bialkowska Book 2015 Springer International Publishing Switzerl
描述.This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field..Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work. .
出版日期Book 2015
关键词colon cancer; colorectal cancer; hereditary crc; microbiome; signaling pathways
版次1
doihttps://doi.org/10.1007/978-3-319-19986-3
isbn_softcover978-3-319-34624-3
isbn_ebook978-3-319-19986-3
copyrightSpringer International Publishing Switzerland 2015
The information of publication is updating

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Microsatellite Instability and Intestinal Tumorigenesis,s crucial to maintaining genetic integrity. When mismatch repair is defective, microsatellite instability occurs, resulting in deregulated tissue growth and tumorigenesis. Although defunct mismatch repair proteins can occur sporadically, these defects are the hallmark of Lynch syndrome, a hereditary
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Biology of Intestinal Epithelial Stem Cells,vide a selective barrier to the noxious lumenal contents, and provide feedback to regulate digestive functions. To achieve these roles, the epithelium is composed of several distinct cell types with different capabilities, including absorptive enterocytes/colonocytes, microfold, goblet, enteroendocr
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Inflammation and Colorectal Cancer,n, progression and metastasis of colon cancer. Colitis associated colon cancer (CAC) is a classic example of multifactorial, multi-step colorectal cancer associated with inflammatory bowel diseases. In recent years, the generation of animal models of CAC and recognition of the importance of the gut
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Sphingolipids in Intestinal Inflammation and Tumorigenesis,only as structural lipids in cell, but mediate significant biologic functions as well. Sphingolipid enzymes function in the intestinal lumen to degrade exogenous dietary sphingolipids and in the enterocytes themselves to generate endogenous sphingolipids. Among the most studied bioactive sphingolipi
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Aging: An Etiological Factor in The Development of Intestinal Tumorigenesis, the age-related rise in sporadic CRC, including altered carcinogen metabolism and the cumulative effects of long-term exposure to cancer-causing agents. In this review article we have discussed the current evidence that implicates aging as an etiological factor in the initiation and progression of
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