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Titlebook: Inorganic and Nutritional Aspects of Cancer; Proceedings of the F G. N. Schrauzer Conference proceedings 1978 The Editor(s) (if applicable)

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An Overview of Metal Carcinogenesis cancer among certain industrial workers. This phenomenon was first noted in the 1880s but did not result in laboratory investigations. Virchow, one of the early pioneering pathologists, suggested that this cancer rise could be linked to a “chronic irritation theory”, but this explanation stirred no imaginative research.
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Infidelity of DNA Synthesis as Related to Mutagenesis and Carcinogenesise have asked how the cell accurately copies DNA, and whether chemical carcinogens perturb this fidelity. This has involved a study of the copying . of polynucleotides by DNA polymerases and the determination of the effects of mutagens and carcinogens on the accuracy of this copying.
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Noble Metal Complexes in Cancer Chemotherapy, but most likely involves a primary lesion on nuclear DNA and the stimulation of a host reaction to the cancer. So far, only square planar and octahedral complexes of platinum, with a variety of inorganic and organic ligands, have shown marked activity in animal studies.
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Potential Carcinostatic Activity of Metal Complexesy these potential donor groups, but not so labile as to be attacked effectively by the many types of normal proteins and DNA in living systems. They also reported the synthesis of several metal complexes that are active against various tumor systems.
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