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Titlebook: Information Processing in Cells and Tissues; 9th International Co Michael A. Lones,Stephen L. Smith,Martin A. Trefze Conference proceedings

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Evolving Locomotion for a Simulated 12-DOF Quadruped RobotUsing a simplistic control architecture and a physics simulation of the robot, gaits are designed both by hand and using a highly parallel evolutionary algorithm (EA). It is found that the EA produces, in a small fraction of the time that takes to design by hand, gaits that travel at nearly twice the speed of the hand-designed one.
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The Effect of Different Types of Synaptic Plasticity on the Performance of Associative Memory Networified models of associative memory with a variety of allowed synaptic plasticity regimes. We show that the allowed synaptic plasticity does indeed have a large effect on the performance of the network and that some regimes are much better than others.
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Systems Biology Analysis of Kinase Inhibitor Protein Target Profiles in Leukemia Treatmentsy-purified and identified by mass spectrometry[2, 3]. Compound-protein interactions are measured in a biological context as opposed to in . binding assays. That is, drugprotein interactions can not only be determined proteome-wide, but also in a tissue- or cell type-dependent manner.
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Tailored Strategies for the Analysis of Metabolomic Data. Using a random matrix theory (RMT) approach, U87 is found to have a modular structure, whereas hMSC does not. The datasets are then compared using between groups comparison of principal components, and finally, a group of metabolites is found that remains highly correlated in both conditions.
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Simulating Neurons in Reaction-Diffusion Chemistrytor, and that a catalyst-free region acts as a threshold on the initiation of an outgoing wave. Spiking neuron models can be mapped onto this system, and therefore RD systems can be used for computation using the same models as are applied to spiking neurons.
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Conference proceedings 2012signalling pathways and responses, protein structure and metabolic networks, patterning and rhythm generation, neural modelling and neural networks, biomedical modelling and signal processing, information processing and representation, and algorithmic approaches in computational biology.
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The Effect of Membrane Receptor Clustering on Spatio-temporal Cell Signalling Dynamicsarent affinity of clustered receptors is decreased. Additionally, receptor occupation becomes spatially and temporally correlated, as clustering creates platforms of coherently activated receptors. Changes in the spatial characteristics of a signalling system at the microscopic scale globally affect
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Multispecific Interactions in Enzymatic Signalling Cascadesitch becoming biphasic. These results indicate how important the rules governing the occurrence of protein-protein interactions can be in determining the signalling behaviour of a pathway, even when particular protein-protein interactions have no clear functional role.
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