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Titlebook: Inflammatory Processes:; Molecular Mechanisms L. Gordon Letts,Douglas W. Morgan Conference proceedings 2000 Springer Basel AG 2000 Chemokin

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Small molecule regulators of AP-1 and NF-кBroteinases [1]. AP-1 includes members of the Jun and Fos families of transcription factors, which are characterized by basic region-leucine zipper (bZIP) DNA-binding domains. AP-1 proteins bind to DNA and activate transcription as Jun homodimers, Jun-Jun heterodimers, or Jun-Fos heterodimers. There
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Macrophage metalloproteinases in destructive inflammatory diseasesl aortic aneurysms, tumor invasion, arthritis, and emphysema. This has led to the hypothesis that aberrant expression of MMPs causes tissue destruction. The macrophage, intimately associated with these inflammatory diseases is a rich source of MMPs. Interestingly, both emphysema and aortic aneurysms
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Chemokine/cytokine biology during the evolution of fibrotic diseasene and fibrotic processes have been implicated in the evolution of these disorders. These processes include potential viral infections [1], genetic variations [2], immune complexes [3], environmental factors [4] and effector cell activation [5]. This last category has generated recent interest, as t
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