| 书目名称 | Inflammasomes: Clinical and Therapeutic Implications |
| 编辑 | Mario D. Cordero,Elísabet Alcocer-Gómez |
| 视频video | http://file.papertrans.cn/465/464663/464663.mp4 |
| 概述 | Extensive coverage of the roles played by inflammasomes in various diseases.Examines the inflammasome as a potential therapeutic target.Discusses pharmacological developments in inflammasome inhibitio |
| 丛书名称 | Experientia Supplementum |
| 图书封面 |  |
| 描述 | .The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts..Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological |
| 出版日期 | Book 2018 |
| 关键词 | Inflammasome; Inhibitor; Sensor; Cytokine; Metabolic stress |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-89390-7 |
| isbn_softcover | 978-3-030-07758-7 |
| isbn_ebook | 978-3-319-89390-7Series ISSN 1664-431X Series E-ISSN 2504-3692 |
| issn_series | 1664-431X |
| copyright | Springer International Publishing AG, part of Springer Nature 2018 |
|Archiver|手机版|小黑屋|
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