| 书目名称 | Implications of the Blood-Brain Barrier and Its Manipulation | | 副标题 | Volume 1 Basic Scien | | 编辑 | Edward A. Neuwelt | | 视频video | | | 图书封面 |  | | 描述 | Understanding the structure and function of the blood-brain barrier (BBB) and recogniz ing its clinical relevance require a concert of scientific disciplines applied from a view point of integrative physiology rather than from only molecular or analytical approaches. It is this broad scope that is emphasized in this book. In my opinion, four original contributions define the field as it exists today. The first, a monograph by Broman,1 entitled The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions, was the model for many subsequent clinical and 3 experimental studies on BBB pathology. Second, experiments by Davson, summarized in his book entitled Physiology of the Ocular and Cerebrospinal Fluids, indicated that passive entry of nonelectrolytes into brain from blood is governed largely by their lipid 4 solubility. This research supported the original suggestion by Gesell and Hertzman that cerebral membranes have the semipermeability properties of cell membranes. The modem era of the barrier was introduced with the 1965 paper by Crone,2 entitled "Facilitated transfer of glucose from blood to brain tissue. " This paper identified stereospecific, facilita | | 出版日期 | Book 1989 | | 关键词 | Nervous System; Parkinson; brain; brain injury; brain tumor; central nervous system; pathophysiology; physi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4613-0701-3 | | isbn_softcover | 978-1-4612-8039-2 | | isbn_ebook | 978-1-4613-0701-3 | | copyright | Plenum Publishing Corporation 1989 |
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发表于 2025-3-21 16:21:58
