| 书目名称 | Impact of Survivin Acetylation on its Biological Function |
| 编辑 | David Dannheisig |
| 视频video | |
| 概述 | Study on the Biological Function of Survivin.Includes supplementary material: |
| 丛书名称 | BestMasters |
| 图书封面 |  |
| 描述 | .In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be usedto examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.. |
| 出版日期 | Book 2017 |
| 关键词 | FRET; Survivin Acetylierung; Proteininteraktionsstudien; Proximity Ligation Assay (PLA); Zellbiologie; Ca |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-658-18623-4 |
| isbn_softcover | 978-3-658-18622-7 |
| isbn_ebook | 978-3-658-18623-4Series ISSN 2625-3577 Series E-ISSN 2625-3615 |
| issn_series | 2625-3577 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wies |
发表于 2025-3-21 18:13:46
