Titlebook: Immunology of Endocrine Diseases; Alan M. McGregor (Senior Lecturer and Honorary Con Book 1986 MTP Press Limited 1986 Antigen.Diabetes.Ins

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Recent Developments in the , Bioassay of TSH and Thyroid-Stimulating Antibodies,e now established as important pathogenetic factors in the hyperthyroidism of Graves’ disease. They appear to interact with a site on or close to the TSH receptor and generally mimic the bioactivity of TSH. It has now become apparent that another group of related antibodies may specifically or prefe

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Insulin Antibodies,its tertiary structure is fully documented; insulin is the most frequently injected highly purified polypeptide used in medicine, and it is readily available, as are species variants, chemically modified insulins and molecular fragments. Most research over the years has been concerned with the immun

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Immunogenetics of Diabetes,ed as a single disease. It is now clear that there are at least two major types of diabetes which are aetiologically distinct, although they have similar long-term complications. The recent WHO classification of diabetes includes these two categories:

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HLA-DR Antigen Expression and Autoimmunity,ible for the rejection of tissue grafts and graft-versus-host reactions, molecules encoded by MHC genes are directly involved in the recognition of antigen by T-cells. The MHC also determines to a great extent whether or not a particular antigen will evoke an immune response. The chapter begins with

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,Observations on Graves’ Ophthalmopathy; Pathology and Pathogenesis,ut observations relating exophthalmos to goitre can be found as early as the 12th century. Despite the growth of a vast literature, considerable uncertainty exists regarding many aspects of this potentially distressing and disfiguring clinical condition, particularly with regard to its pathogenesis

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Immunogenetics of Diabetes,ed as a single disease. It is now clear that there are at least two major types of diabetes which are aetiologically distinct, although they have similar long-term complications. The recent WHO classification of diabetes includes these two categories: