Titlebook: Immunological Aspects of Rheumatology; W. Carson Dick Book 1981 MTP Press Limited 1981 rheumatology

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Autoantibodies in the Rheumatic Diseases,rly in the early stages of disease, and as the quantitation of these antibodies has become increasingly reproducible their levels have often been shown to have both prognostic significance and value in monitoring response to therapy.

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Antigen-Antibody Complexes: Their Nature and Role in Animal Models of Antigen-Antibody Complex Diseses. This interest in the pathogenicity of antigen-antibody complexes un human disease has developed directly as a result of extensive laboratory work on animal models, particularly of glomerulonephritis.

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,The Macrophage—Origins, Functions and Role in the Rheumatic Diseases,of the mononuclear series may play a key role in the initiation., and genetic regulation. of the immune response as well as being an important source of inflammatory mediators and destructive enzymes. Yet these cells have been little studied in rheumatoid arthritis (RA) and other inflammatory connective tissue disorders.

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Harass

,Polymorphonuclear Leukocytes (PMN)—Origins, Functions and Roles in the Rheumatic Diseases,lly. This review will therefore not aim to be an exhaustive examination of all available literature but will attempt to summarize areas where a general consensus has been reached and to provide an overview of current thoughts on the role of the polymorph in the pathophysiology of some of the rheumatic diseases.

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Eosinophils and the Connective Tissue Diseases,e an indication that the cell has little part to play in the pathogenesis of the rheumatic diseases although this need not necessarily be the case, there being some experimental evidence that eosinophils are involved in immune complex-mediated, complement-mediated and certain delayed hypersensitivity reactions.

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