| 书目名称 | Immunological Adjuvants and Vaccines | | 编辑 | Gregory Gregoriadis,Anthony C. Allison,George Post | | 视频video | | | 丛书名称 | NATO Science Series A: | | 图书封面 |  | | 描述 | Vaccination, chiefly responsible for the eradication of smallpox and the control of poliomyelitis and German measles in man and of foot-and mouth, Marek‘s and Newcastle disease in domestic animals, remains the best answer to infectious diseases. Early vaccines were live wild type organ isms but these have been largely replaced by attenuated or killed organisms or by purified components (subunits) thereof. More recently, developments in recombinant DNA techniques, the advent of monoclonal antibodies and progress in our understanding of the immunological structure of proteins, have laid the foundations for a new generation of vaccines. For instance, subuni t vaccines have been produced through gene cloning and a number of peptides mimicking small regions of proteins on the outer coat of viruses and capable of eliciting virus neutralizing antibodies, have been synthes ized. Such vaccines are defined at the molecular level, can elicit immune responses controlling specific infectious organisms and are, thus, potent ially free of the problems inherent in conventional ones. However, because subunit and peptide vaccines are only weakly or non-immunogenic, they re quire the presence of | | 出版日期 | Book 1989 | | 关键词 | Antigen; DNA; gene expression; infectious disease; interferon; proteins | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4757-0283-5 | | isbn_softcover | 978-1-4757-0285-9 | | isbn_ebook | 978-1-4757-0283-5 | | copyright | Springer Science+Business Media New York 1989 |
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发表于 2025-3-21 19:57:11
