Titlebook: Immunobiology of Proteins and Peptides VII; Unwanted Immune Resp M. Zouhair Atassi Book 1994 The Editor(s) (if applicable) and The Author(s

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Is there a Link Between the Nature of Agents that Trigger Mast Cells and the Induction of Immunogloggerated fashion. The term was originally coined by Pirquet in 1906, meaning “altered reactivity”, it was used to characterise the change in reaction which has occurred following exposure to an antigen. Present day immunologists attribute the manifestations of allergy to a condition where the immune

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Immunogenetic Aspects of IgE-Mediated Responses,ear . relationship has been established between the clinical expression of specific allergies and the induction of specific IgE antibody (Ab) responses.. Several studies have provided evidence for at least two types of genetic control of IgE responses in humans, namely, non-.-linked control of the o

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,Characterization of the Human IgE Fc-Fc∈RIα Interaction,t triggers the release of a variety of inflammatory mediators, including histamine, leukotrienes, and cytokines that contribute to the allergic condition. The Fc∈RI is composed of at least three different subunits α, . and γ, in the rodent and the human (reviewed in Ravetch and Kinet, 1991) (figure

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The Immunogenetic Basis of Collagen Induced Arthritis in Mice: An Experimental Model for the Rationa of intense investigation over the past two decades. During this period, various experimental animal models of RA have been studied which have contributed greatly to our basic understanding of this disease. One model of particular interest is the mouse model of collagen induced arthritis (CIA). Fol

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Suppression of Experimental Autoimmune Myasthenia Gravis by Epitope-Specific Neonatal Tolerance,in HLA antigens (3), and linked to a polymorphism in the HLA-DQß subunit (4). Immunization of C57BL6(B6) mice with Torpedo californica AChR (T-AChR) produces an autoimmune disease mimicking MG called experimental autoimmune myasthenia gravis (EAMG). EAMG susceptibility has been mapped to the I-A sub

MEAN

T Cell Reactivity to Self and Allogeneic MHC-Peptides,of self-non-self discrimination. This is particularly important in the case of MHC antigens since these molecules serve as restriction elements for T cell recognition of endogenous and exogenous peptides. It is presumed, although not yet proven, that T cells capable of reacting to self-MHC molecules

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Cross-Reactions of Anti-Immunoglobulin Sera with Synthetic T-Cell Receptor , Peptides: Mapping on aning, and constant regions. We assessed the cross-reactivity between Tcr . chains and immunoglobulin light chains by determining the capacity of rabbit antisera to human or murine immunoglobulins to react to a synthesized set of nested, overlapping 16-mer peptides corresponding to the VDJC sequence