Titlebook: IgM and Its Receptors and Binding Proteins; Hiromi Kubagawa,Peter D. Burrows Book 2017 The Editor(s) (if applicable) and The Author(s), un

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,Authentic IgM Fc Receptor (FcμR),ine FcµR. In this short article, we will discuss recent findings from us and other investigators along with our interpretations and comments that may help to resolve the existing puzzles and should open new avenues of investigation.

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The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution,dual receptor for IgA/IgM (FcαµR) and the IgM receptor (FcµR). All of them are related in structure and located in the same chromosomal region in mammals. The functions of the PIGRs are to transport IgM and IgA into the intestinal lumen and to saliva and tears, whereas the FcαµRs enhance uptake of i

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,FCRLA—A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypend unique features. It is a soluble resident ER protein retained in this organelle by unknown mechanisms involving the N-terminal domain, a disordered domain with three Cys residues in close proximity in the human protein. Unlike the FcγRs, FCRLA is not glycosylated and has no transmembrane region.

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Role of Natural IgM Autoantibodies (IgM-NAA) and IgM Anti-Leukocyte Antibodies (IgM-ALA) in Regulatneoantigens. IgM-NAA achieve this difficult task by being polyreactive with low binding affinity but with high avidity, characteristics that allow these antibodies to bind antigenic determinants shared by pathogens and neoantigens. Hence the same clones of natural IgM can bind and mask host neoantig

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ental governance. These mechanisms are, however, under pressure from a range of processes and impacts. Challenges including data availability and lack of comprehensive data collection, unstandardized reporting formats, unsystematic monitoring processes, and fragmentation in international environment

CANE

Srinivas Akula,Lars Hellmanl regime that governs the Antarctic. Next, possible futures of the Antarctic Treaty System (ATS) are examined in the context of China’s rise. The ATS has generally been praised as a success for maintaining peace and security in the Antarctic. Questions have, however, been raised in recent years beca