Titlebook: IgE Receptor (FcεRI) Function in Mast Cells and Basophils; Majed M. Hamawy Book 1997 Springer-Verlag Berlin Heidelberg 1997 asthma.disease

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,Protein Tyrosine Phosphatases in Signaling Through the FcεRI on Mast Cells and Basophils,ation and activation.. The level of protein tyrosine phosphorylation within a cell reflects a dynamic balance between the often competing activities of the protein tyrosine kinases that phosphorylate proteins and the protein tyrosine phosphatases (PTPs) that dephosphorylate them. It is the shift in

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Regulation and Roles of the Membrane, Cytoskeletal and Adhesive Responses of RBL-2H3 Rat Tumor Mastosslinking causes degranulation, releasing inflammatory agents that initiate the immediate hypersensitivity diseases including allergy, asthma and anaphylaxis. Receptor crosslinking also stimulates the production of lipid mediators that amplify the immediate inflammatory response and of cytokines th

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,Signal Transduction Pathways Regulating Arachidonic Acid Metabolite Generation Following FcεRI Aggr events that lead to degranulation, cytokine gene expression and the de novo synthesis and release of phospholipid-derived pro-in- flammatory mediators. The phospholipid-derived category of inflamma- tory mediators includes cyclooxygenase-derived products such as prostag- landin (PG) D., 6-keto-PGF1

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,FcεRI-induced Cytokine Production and Gene Expression,ago that is was first shown that some transformed mast cell lines could secrete these proteins. Since then we have come to understand that normal mast cells and basophils, the cells that we most commonly associate with the FcεRI and IgE-dependent responses, may also secrete a wide array of cytokines