| 书目名称 | Homocysteine and Vascular Disease | | 编辑 | Killian Robinson | | 视频video | | | 丛书名称 | Developments in Cardiovascular Medicine | | 图书封面 |  | | 描述 | This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was ap | | 出版日期 | Book 2000 | | 关键词 | cardiovascular; coronary artery disease; coronary heart disease; heart disease; molecular biology; stroke | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-017-1789-2 | | isbn_softcover | 978-90-481-5431-9 | | isbn_ebook | 978-94-017-1789-2Series ISSN 0166-9842 | | issn_series | 0166-9842 | | copyright | Springer Science+Business Media Dordrecht 2000 |
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发表于 2025-3-21 16:26:38
