Titlebook: Histone Deacetylases; Methods and Protocol Sibaji Sarkar Book 2016 Springer Science+Business Media New York 2016 epigenetics.deacetylation

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Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4)I further divided into two subclasses: IIa (HDAC4, HDAC5, HDAC7, HDAC9) and IIb (HDAC6 and HDAC10). While HDAC6 is mainly cytoplasmic and HDAC10 is pancellular, class IIa HDACs are dynamically shuttled between the nucleus and cytoplasm in a signal-dependent manner, indicating that they are unique si

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Analysis of Histone Deacetylase 7 (HDAC7) Alternative Splicing and Its Role in Embryonic Stem Cell D (ES) cell differentiation. Alternative splicing gives rise to vast diversity over gene information, arousing public concerns in the last decade. In this chapter, we describe a strategy to detect HDAC7 alternative splicing and analyze its function on ES cell differentiation.

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Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Hucellular programs thus represents an Achilles’ heel of human parasites. Today, zinc-dependent histone deacetylases (HDACs) belong to the most explored epigenetic drug targets in eukaryotic parasites. Here, we describe an optimized protocol for the large-scale overproduction and purification of recom

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Expression and Function of Histone Deacetylase 10 (HDAC10) in B Cell Malignanciesn has been reported in patients with aggressive solid tumors (Osada et al. Int J Cancer 112: 26–32, 2004; Jin et al. Int J Clin Exp Pathol 7: 5872–5879, 2014), suggesting that loss of HDAC10 expression might confer a survival advantage to malignant cells. Consequently, results from our lab suggests

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Functional Analysis of Histone Deacetylase 11 (HDAC11)egulatory function in immune cells. Among them, the regulation of cytokine production by antigen-presenting cells and the modulation of the suppressive ability of myeloid-derived suppressor cells (MDSCs) (Sahakian et al. Mol Immunol 63: 579–585, 2015; Wang et al. J Immunol 186: 3986–3996, 2011; Vill

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Sirtuin1 (SIRT1) in the Acetylation of Downstream Target Proteinss in cell signaling and transcriptional regulation of gene expression. Many studies have already demonstrated that SIRT1 is able to deacetylate histones and lead to gene silencing. It can also regulate the function of tumor suppressors including FOXO proteins and p53 by deacetylation. Here, we descr

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