Titlebook: Hirschsprung‘s Disease and Allied Disorders; Alexander Matthias Holschneider,Prem Puri Book 20083rd edition Springer-Verlag Berlin Heidelb

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Functional Anatomy of the Enteric Nervous System, human illness by studying animal models, than by investigating the patients themselves. Invasive research, which is only possible on animals, can be used to develop a conceptual framework to devise hypotheses that can subsequently be tested for applicability to human patients. Experiments, based on

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,The Molecular Genetics of Hirschsprung’s Disease,rths, with the highest incidence in Asian populations (2.8 in 10,000), intermediate in Afro-Americans (2.1 in 10,000) and Caucasians (1.5 in 10,000) and lowest in Hispanics (1 in 10,000). The male to female ratio is 4:1, and the sex imbalance is particularly evident for S-forms (ranging from 4.2 to

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Springer-Verlag Berlin Heidelberg 2008

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Alexander Matthias Holschneider,Prem PuriThe definite reference on Hirschsprung‘s Disease now in its third edition.International update on its science and surgery.Special emphasis on laparoscopic approach.Includes supplementary material:

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,Pathophysiology of Hirschsprung’s Disease,t that prevents the propagation of peristaltic waves. Despite extensive research, the pathophysiology of HD is not fully understood. There is no clear explanation for the occurrence of spastic or tonically contracted aganglionic segment of bowel.

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,Diagnosis of Hirschsprung’s Disease and Allied Disorders,reening procedure, radiology still has an important role to play. The diagnosis of Hirschsprung’s disease may be suggested on plain films, which may also demonstrate the serious complication of enterocolitis. Barium enema is usually diagnostic and should show both the transition zone and the length of the distal aganglionic segment of bowel.