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Titlebook: High-Risk Cutaneous Squamous Cell Carcinoma; A Practical Guide fo Chrysalyne D. Schmults Book 2016 Springer-Verlag Berlin Heidelberg 2016 M

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书目名称High-Risk Cutaneous Squamous Cell Carcinoma
副标题A Practical Guide fo
编辑Chrysalyne D. Schmults
视频video
概述Only text devoted to squamous cell carcinoma of the skin with a focus on high-risk tumors that may recur or metastasize.Summaries of new prognostic information and staging systems allowing more precis
图书封面Titlebook: High-Risk Cutaneous Squamous Cell Carcinoma; A Practical Guide fo Chrysalyne D. Schmults Book 2016 Springer-Verlag Berlin Heidelberg 2016 M
描述.This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.​.
出版日期Book 2016
关键词Metastatic disease; Molecular and genetic factors; Multiple and high-risk tumors; Non-melanoma skin can
版次1
doihttps://doi.org/10.1007/978-3-662-47081-7
isbn_softcover978-3-662-56891-0
isbn_ebook978-3-662-47081-7
copyrightSpringer-Verlag Berlin Heidelberg 2016
The information of publication is updating

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Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-Risk Cutuppression, all of which contribute to squamous carcinogenesis. UV-carcinogenesis is understood mechanistically, causing a specific mutational ‘fingerprint’, but the extensive chromosomal aberrations causing gene copy number alterations and the massive burden of gene mutations make it very difficult
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Management of High-Risk Primary Tumors Including Nodal Staging as common as that from melanoma, renal carcinoma and oropharyngeal carcinoma. While most CSCCs are easily treatable and curable, this textbook focuses on the high-risk subset of CSCC which exhibits more aggressive behavior and has a significant risk of recurrence. While many treatment options exist
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Management of Nodal Metastasesses to draining regional lymph nodes. Most cSCC arise on the sun-exposed head and neck (HN) and subsequently the parotid and cervical nodes are the most frequent sites for the development of nodal metastases. Less frequently encountered are metastatic nodes involving the axilla or groin arising from
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Immune Dysfunction and Immunosuppression: Impacts on SCC Incidence, Prognosis, and Managementimmune dysfunction which serves as a nidus for many keratinocytic malignancies. Furthermore, patients with systemic immune dysfunction or dysregulation are subject to forming multiple SCCs and have a higher risk of developing biologically aggressive tumors. Proper balancing and targeting of immune f
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