| 书目名称 | Hidden Treasures in Contemporary RNA Sequencing | | 编辑 | Serghei Mangul,Harry Taegyun Yang,Noah Zaitlen | | 视频video | http://file.papertrans.cn/427/426115/426115.mp4 | | 概述 | Focuses on revealing the features hidden in unmapped reads, which traditional RNA-sequencing research commonly regards as uninformative.Highlights how a comprehensive search for the origin of unmapped | | 丛书名称 | SpringerBriefs in Computer Science | | 图书封面 |  | | 描述 | Advances in RNA-sequencing (RNA-seq) technologies have provided an unprecedented opportunity to explore the gene expression landscape across individuals, tissues, and environments by efficiently profiling the RNA sequences present in the samples. When a reference genome sequence or a transcriptome of the sample is available, mapping-based RNA-seq analysis protocols align the RNA-seq reads to the reference sequences, identify novel transcripts, and quantify the abundance of expressed transcripts..The reads that fail to map to the human reference, known as unmapped reads, are a large and often overlooked output of standard RNA-seq analyses. Even in carefully executed experiments, the unmapped reads can comprise a considerable fraction of the complete set of reads produced, and can arise due to technical sequencing produced by low-quality and error-prone copies of the nascent RNA sequence being sampled. Reads can also remain unmapped due to unknown transcripts, recombined Band T cell receptor sequences, A-to-G mismatches from A-to-I RNA editing, trans-splicing, gene fusion, circular RNAs, and the presence of non-host RNA sequences (e.g. bacterial, fungal, and viral organisms). Unmappe | | 出版日期 | Book 2019 | | 关键词 | Next-Generation Sequencing; RNA Sequencing; Transcriptomics; Read Mapping; Circular RNAs; Gene Fusions; Im | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-13973-5 | | isbn_softcover | 978-3-030-13972-8 | | isbn_ebook | 978-3-030-13973-5Series ISSN 2191-5768 Series E-ISSN 2191-5776 | | issn_series | 2191-5768 | | copyright | The Author(s), under exclusive license to Springer Nature Switzerland AG 2019 |
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