| 书目名称 | Heat Shock Proteins in Human Diseases |
| 编辑 | Alexzander A. A. Asea,Punit Kaur |
| 视频video | |
| 概述 | Provides the most comprehensive review of contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases.Contains chapters contributed by specialists from key basic a |
| 丛书名称 | Heat Shock Proteins |
| 图书封面 |  |
| 描述 | .The book .Heat Shock Proteins in Cancer Therapeutics .provides the most comprehensive review on contemporary knowledge on the role of HSP in various types of cancer therapeutics. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in cancer therapeutics..The heat shock response pathway is a highly conserved cellular process. Heat shock factors are a master transcriptional regulator responsible for expression of several important heat shock proteins, which can effectively protect critical client proteins from misfolding and degradation, thus maintaining intracellular integrity under stressed conditions. Recent studies have demonstrated the direct connections between heat shock response players and tumor cell survival, validating heat shock response players as novel molecular targets in anticancer treatment. Although many hurdles in clinical application still need to be effectively addressed, such as undesirable drug toxicity and off target effects; narrow therapeutic window; poor PK/PD profiles, etc. Recent reports on synergistic drug combination, advanced prodrug design, smart nanoparticle packaging, and RNA aptamer se |
| 出版日期 | Book 2021 |
| 关键词 | Chaperone; Cancer; Inflammatory Diseases; Immunity; Molecular Therapy |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-030-62289-3 |
| isbn_softcover | 978-3-030-62291-6 |
| isbn_ebook | 978-3-030-62289-3Series ISSN 1877-1246 Series E-ISSN 1877-1254 |
| issn_series | 1877-1246 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
发表于 2025-3-21 19:39:11
