Titlebook: Handbook of Neurochemistry and Molecular Neurobiology; Acute Ischemic Injur Abel Lajtha (Director),Pak H. Chan (Director Neuro Reference wo

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Gene Expression Profiling in Ischemic Brain Injury and Ischemic Tolerance,lls survive ischemia. A genomic approach may identify and characterize these genes and the neuroprotective pathways through which their protein products operate. Identification of gene products that are endogenous neuroprotectants contributes significantly to our understanding of the pathophysiology

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eNOS and nNOS in Stroke, of cerebral blood flow, and coupling of blood flow to metabolism. NO generated by the three isoforms of nitric oxide synthase (NOS), endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS), plays distinct roles. Following cerebral ischemia, NO levels rise dramatically, and NO can be e

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The Role of Glia in Excitotoxicity and Stroke,n ischemia and excitotoxicity. Of the three types of glia in the central nervous system—astrocytes, oligodendrocytes, and microglia—the role of astrocytes in excitotoxicity and ischemia has been best characterized. Under different settings, astrocytes can both limit or contribute to excitotoxic neur

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