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Titlebook: HRT and Osteoporosis; James O. Drife (Professor of Obstetrics and Gynaec Conference proceedings 1990 Springer-Verlag London Limited 1990 O

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https://doi.org/10.1057/978023033955250 years ago, postmenopausal oestrogen use did not gain popularity until the 1950s and 1960s, with the USA at the forefront. In the 1970s reports emerged of an apparent rise in the incidence of endometrial carcinoma in women given unopposed oestrogen [3,4]. Although these studies documented a five-
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Biology of the Menopausespend approximately one-third of their life in the menopausal state. By definition the menopause is the last menstrual period and its timing can only be determined in retrospect; by convention if there has been no spontaneous period for 12 months, ovarian failure with consequent lack of menstrual bl
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Oestrogen Deficiency and the Bladderrogenital membrane produces the ectodermal covering of the vulva and external urethral meatus. Animal and human studies have shown that the urethra is oestrogen sensitive, and in the human female oestrogen receptors are present in both the urethra and the bladder. Thus it is logical to suppose that
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