Titlebook: HLA Typing; Methods and Protocol Sebastian Boegel Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Next generat

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Adlai Stevenson: Hamlet in New York,tatistical analysis of large population-specific genotype samples. As established tools for the latter approach lacked ability to treat the amount, ambiguity, and inhomogeneity found in genotype data in hematopoietic stem cell donor registries, we developed Hapl-o-Mat to alleviate these specific shortcomings.

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HLA Typing from Short-Read Sequencing Data with OptiType,ta has prompted a demand for computational tools capable of HLA typing from general purpose sequencing data as well. OptiType is a software that performs HLA typing from short-read DNA and RNA sequencing data, and this chapter guides the user through its installation and usage.

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,HLA Haplotype Frequency Estimation from Real-Life Data with the Hapl-o-Mat Software,tatistical analysis of large population-specific genotype samples. As established tools for the latter approach lacked ability to treat the amount, ambiguity, and inhomogeneity found in genotype data in hematopoietic stem cell donor registries, we developed Hapl-o-Mat to alleviate these specific shortcomings.

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https://doi.org/10.1007/978-3-658-39970-2 using SNP data. Two examples are provided to illustrate with a publicly available HLA and SNP dataset: genotype imputation with pre-fit classifiers in GWAS, and model training to build a new classifier.

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