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Titlebook: Genome Integrity; Facets and Perspecti Dirk-Henner Lankenau Book 2007 Springer-Verlag Berlin Heidelberg 2007 Chromosom.DNA.DNA Repair.Genet

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书目名称Genome Integrity
副标题Facets and Perspecti
编辑Dirk-Henner Lankenau
视频video
概述First book to give a full overview on genome integrity in different species.Spans from microorganisms to humans.Addresses the connection between genome integrity and human disease.Written by an intern
丛书名称Genome Dynamics and Stability
图书封面Titlebook: Genome Integrity; Facets and Perspecti Dirk-Henner Lankenau Book 2007 Springer-Verlag Berlin Heidelberg 2007 Chromosom.DNA.DNA Repair.Genet
描述.Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed..
出版日期Book 2007
关键词Chromosom; DNA; DNA Repair; Genetics; Genome Dynamics; Genome Integrity; Replication; Viruses; base; chromoso
版次1
doihttps://doi.org/10.1007/b104871
isbn_softcover978-3-642-07226-0
isbn_ebook978-3-540-37531-9Series ISSN 1861-3373 Series E-ISSN 1861-3381
issn_series 1861-3373
copyrightSpringer-Verlag Berlin Heidelberg 2007
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DNA Polymerases and Diseasesalso critically evaluating those cases where the experimental data are not fully convincing. To this aim, we will first give a short overview of the three main DNA metabolic events, namely replication, repair and recombination, as well as of the checkpoint pathways acting in response to DNA damage.
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Germline Double-Strand Break Repair and Gene Targeting in ,: A Trajectory System throughout Evolutio of metazoans. In contrast, most studies concerning DNArepair in mammals focused on somatic cells while only few authors engaged in embryonic stem cells. . represents a field of in vivo biochemistry systems linking DNArepair research with the power of classical genetics and modern developmental, mol
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Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assaysning (NHEJ) is the major pathway of DSB repair.Genetic studies in yeast, human and rodent cell lines displaying increased IR sensitivity and defects inDSB repair have provided insight in the genes involved in NHEJ. These genetic data have been confirmed andcomplemented by in vitro assays which have
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Role of p53 in Double-Strand Break Repairdouble-strand break repair. In this review, we summarize datafrom biochemical, cell based and in vivo approaches demonstrating that wild-type p53 restrains excessiveand mutagenic DNA exchange events. Thus, p53 appears to exhibit fidelity control of homologous recombination,and recent evidence also s
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